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| West Ham – Chelsea | 0:0 (end) | | | Arsenal – Everton | 2:0 (end) |
| Levante – Sevilla | 2:6 (end) | | | Villarreal – Valencia | 0:0 (end) | | | Betis – Bilbao | 2:2 (end) |
| Barcelona – Girona | 2:2 (end) |
| Leverkusen – Mohuč | 1:0 (end) | | | Frankfurt – RB Leipzig | 1:1 (end) |
| Feyenoord – Utrecht | 1:0 (end) | | | Emmen – Zwolle | 0:1 (end) | | | Groningen – Alkmaar | 1:3 (end) |
| Eindhoven – Ajax | 3:0 (end) |
| Gent – Club Brugge | 0:4 (end) | | | Anderlecht – Standard | 2:1 (end) |
| Setúbal – Porto | 0:2 (end) | | | Feirense – Nacional | 0:0 (end) | | | Tondela – Moreirense | 2:0 (end) |
| SL Benfica – Aves | 2:0 (end) | | | Portimonense – Guimarães | 3:2 (end) |
| Austria – Linz | 0:3 (end) | | | Wacker – Admira | 1:3 (end) | | | Salzburg – Rapid | 2:1 (end) |
| Grozny – Orenburg | 1:1 (end) | | | FC Zenit – Lok. Moskva | 5:3 (end) | | | CSKA Moskva – Spartak | 1:1 (end) |
| Slavia – Bohemians 1905 | 1:0 (end) |
| Dunajská Streda – Trnava | 3:2 (end) |
final
S. S. Lazio
4:1
(2:0)
Genoa CFC
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90+3
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Game over.
(16:56:43)
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89. Ciro Immobile (LAZ) - 4:1
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89
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Team Lazio with just scored a goal! Scorer is CIRO IMMOBILE.
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86
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S. S. Lazio substitution: Adam Marušić is replaced by Patric.
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80
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Milan Badelj (S. S. Lazio) is shown a yellow card.
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72
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S. S. Lazio substitution: Sergej Milinković-Savić is replaced by Milan Badelj.
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62
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Genoa CFC substitution: Iuri Medeiros is replaced by Sandro.
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62
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S. S. Lazio substitution: Felipe Caicedo is replaced by Joaquín Correa.
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57
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Genoa CFC substitution: Rômulo is replaced by Danko Lazović.
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53. Sergej Milinković-Savić (LAZ) - 3:1
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53
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Team Lazio with just scored a goal! Scorer is SERGEJ MILINKOVIĆ-SAVIĆ. Assisted by Senad Lulić.
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46. Krzysztof Piątek (JAN) - 2:1
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46
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Team Genoa with just scored a goal! Scorer is KRZYSZTOF PIĄTEK.
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46
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Start of 2nd half.
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45+3
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1st halftime finished.
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45+1
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Daniel Bessa (Genoa CFC) is shown a yellow card.
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27
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Genoa CFC substitution: Nicolás Spolli is replaced by Christian Kouamé.
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23. Ciro Immobile (LAZ) - 2:0
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23
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Team Lazio with just scored a goal! Scorer is CIRO IMMOBILE. Assisted by Marco Parolo.
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Goals:
7. F. Caicedo (S. Milinković-Savić), 23. Immobile (Parolo), 53. S. Milinković-Savić (Lulić), 89. Immobile – 46. K. Piątek
Ball possession: 55 % : 45 %.
Shots on target: 8:3. Shots off target: 8:4. Corners: 5:3. Offsides: 1:2. Fouls: 9:7.
Referees: Abisso – Fiorito, Di Iorio
Attendance:
Cards: 80. Badelj (LAZ) – 11. Spolli (JAN), 45+1. Bessa (JAN)
Penalty missed:
Ball possession: 55 % : 45 %.
Shots on target: 8:3. Shots off target: 8:4. Corners: 5:3. Offsides: 1:2. Fouls: 9:7.
S. S. Lazio:
Strakoša – Wallace, Acerbi, Cáceres – Marušić (86. Patric), Parolo, Lucas Leiva, S. Milinković-Savić (72. Badelj), Lulić (C) – Immobile, F. Caicedo (62. Correa).
Subs: Guerrieri, Proto – Basta, Patric, Alberto, Correa, Durmisi, Bastos, Badelj, Cataldi, Jordao, Murgia.
Coach:
Genoa CFC: Marchetti – Biraschi, Spolli (27. Kouamé), E. Zukanović – Günter (C), Rômulo (57. Lazović), Bessa, Hiljemark – Criscito, I. Medeiros (62. Sandro), K. Piątek.
Subs: Vodišek, Radu – L. Mazzitelli, Kouamé, Rolón, Panděv, Dalmonte, Lakićević, P. Pereira, Omeonga, Sandro, Lazović.
Coach:
Subs: Guerrieri, Proto – Basta, Patric, Alberto, Correa, Durmisi, Bastos, Badelj, Cataldi, Jordao, Murgia.
Coach:
Genoa CFC: Marchetti – Biraschi, Spolli (27. Kouamé), E. Zukanović – Günter (C), Rômulo (57. Lazović), Bessa, Hiljemark – Criscito, I. Medeiros (62. Sandro), K. Piątek.
Subs: Vodišek, Radu – L. Mazzitelli, Kouamé, Rolón, Panděv, Dalmonte, Lakićević, P. Pereira, Omeonga, Sandro, Lazović.
Coach:
Referees: Abisso – Fiorito, Di Iorio
Attendance: