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All times are CEST (UTC + 2)
| Burnley – Bournemouth | 4:0 (end) | | | Crystal Palace – Newcastle | 0:0 (end) | | | Leicester – Huddersfield Town | 3:1 (end) |
| Liverpool – Southampton | 3:0 (end) | | | Man Utd. – Wolverhampton | 1:1 (end) |
| Rayo Vallecano – Alavés | 1:5 (end) | | | Celta Vigo – Valladolid | 3:3 (end) | | | Eibar – Leganés | 1:0 (end) |
| Getafe – Atlético | 0:2 (end) | | | Real – Espanyol | 1:0 (end) |
| Augsburg – Bremen | 2:3 (end) | | | Hertha – Mönchengladbach | 4:2 (end) | | | Hoffenheim – Dortmund | 1:1 (end) |
| Norimberk – Hannover | 2:0 (end) | | | Wolfsburg – Freiburg | 1:3 (end) | | | Schalke – Bayern | 0:2 (end) |
| Sittard – Willem II | 4:4 (end) | | | Excelsior – Heerenveen | 3:3 (end) | | | Venlo – Breda | 3:0 (end) |
| Arnhem – Den Haag | 1:1 (end) |
| Waasland-Beveren – Charleroi | 1:1 (end) | | | Eupen – Oostende | 1:2 (end) | | | Lokeren – Mouscron | 0:0 (end) |
| Sint-Truiden – Antwerp | 2:0 (end) |
| Santa Clara – Rio Ave | 1:3 (end) | | | Marítimo – Belenenses | 0:0 (end) | | | Setúbal – Porto | 0:2 (end) |
| Rheindorf Altach – Wolfsberger | 0:1 (end) | | | St. Pölten – Hartberg | 3:0 (end) | | | Sturm Graz – Mattersburg | 1:2 (end) |
| Jenisej – Ural | 1:2 (end) | | | Dynamo – Machačkala | 0:1 (end) | | | Arsenal Tula – Kazaň | 2:2 (end) |
| Grozny – Orenburg | 1:1 (end) | | | Rostov – Ufa | 0:0 (end) |
| Olomouc – Dukla Praha | 1:0 (end) | | | Karviná – Příbram | 4:1 (end) | | | Mladá Boleslav – Slovácko | 5:1 (end) |
| Sparta – Liberec | 4:1 (end) |
| Trenčín – Zlaté Moravce | 1:0 (end) | | | Žilina – Senica | 5:0 (end) | | | Ružomberok – Podbrezová | 3:0 (end) |
Goals:
5. Aspas (Gómez), 10. Gómez, 55. Aspas (Boufal) – 40. Plano (Nacho Martínez), 65. Ünal (Nacho Martínez), 90+4. Leo Suárez (Plano)
Referees:
Attendance:
Cards: 42. Roncaglia (CVG), 49. Juncà (CVG) – 19. Alcaraz (RVL), 25. Čop (RVL)
Penalty missed:
Celta de Vigo:
S. Álvarez – Roncaglia, Costas, N. Araujo, Juncà (59. Alonso) – Lobotka, Yokuşlu – Méndez (82. Beltrán), Aspas (C), Boufal (69. Sisto) – Gómez.
Subs: Blanco – Sisto, Eckert, M. Jensen, Beltrán, Mor, Alonso.
Coach:
Real Valladolid: Masip – Moyano (C) (90+2. Leo Suárez), Olivas, F. Calero, Nacho Martínez – B. Fernández (56. Ünal) – Míchel, Keko (54. T. Villa), Alcaraz, Plano – Čop.
Subs: Ivi López, Antoñito, Moi, Anuar, Ünal, T. Villa, Leo Suárez.
Coach:
Subs: Blanco – Sisto, Eckert, M. Jensen, Beltrán, Mor, Alonso.
Coach:
Real Valladolid: Masip – Moyano (C) (90+2. Leo Suárez), Olivas, F. Calero, Nacho Martínez – B. Fernández (56. Ünal) – Míchel, Keko (54. T. Villa), Alcaraz, Plano – Čop.
Subs: Ivi López, Antoñito, Moi, Anuar, Ünal, T. Villa, Leo Suárez.
Coach:
Referees:
Attendance:
Scorer is LEONARDO SUÁREZ. Assisted by Óscar Plano.
Scorer is ENES ÜNAL. Assisted by Nacho Martínez.
Scorer is IAGO ASPAS. Assisted by Sofiane Boufal.
Scorer is ÓSCAR PLANO. Assisted by Nacho Martínez.