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All times are CEST (UTC + 2)
| Burnley – Bournemouth | 4:0 (end) | | | Crystal Palace – Newcastle | 0:0 (end) | | | Leicester – Huddersfield Town | 3:1 (end) |
| Liverpool – Southampton | 3:0 (end) | | | Man Utd. – Wolverhampton | 1:1 (end) |
| Rayo Vallecano – Alavés | 1:5 (end) | | | Celta Vigo – Valladolid | 3:3 (end) | | | Eibar – Leganés | 1:0 (end) |
| Getafe – Atlético | 0:2 (end) | | | Real – Espanyol | 1:0 (end) |
| Augsburg – Bremen | 2:3 (end) | | | Hertha – Mönchengladbach | 4:2 (end) | | | Hoffenheim – Dortmund | 1:1 (end) |
| Norimberk – Hannover | 2:0 (end) | | | Wolfsburg – Freiburg | 1:3 (end) | | | Schalke – Bayern | 0:2 (end) |
| Sittard – Willem II | 4:4 (end) | | | Excelsior – Heerenveen | 3:3 (end) | | | Venlo – Breda | 3:0 (end) |
| Arnhem – Den Haag | 1:1 (end) |
| Waasland-Beveren – Charleroi | 1:1 (end) | | | Eupen – Oostende | 1:2 (end) | | | Lokeren – Mouscron | 0:0 (end) |
| Sint-Truiden – Antwerp | 2:0 (end) |
| Santa Clara – Rio Ave | 1:3 (end) | | | Marítimo – Belenenses | 0:0 (end) | | | Setúbal – Porto | 0:2 (end) |
| Rheindorf Altach – Wolfsberger | 0:1 (end) | | | St. Pölten – Hartberg | 3:0 (end) | | | Sturm Graz – Mattersburg | 1:2 (end) |
| Jenisej – Ural | 1:2 (end) | | | Dynamo – Machačkala | 0:1 (end) | | | Arsenal Tula – Kazaň | 2:2 (end) |
| Grozny – Orenburg | 1:1 (end) | | | Rostov – Ufa | 0:0 (end) |
| Olomouc – Dukla Praha | 1:0 (end) | | | Karviná – Příbram | 4:1 (end) | | | Mladá Boleslav – Slovácko | 5:1 (end) |
| Sparta – Liberec | 4:1 (end) |
| Trenčín – Zlaté Moravce | 1:0 (end) | | | Žilina – Senica | 5:0 (end) | | | Ružomberok – Podbrezová | 3:0 (end) |
final
Liverpool FC
3:0
(3:0)
Southampton FC
Goals:
10. Hoedt (own), 21. Matip (Alexander-Arnold), 45+3. M. Salah
Ball possession: 61 % : 39 %.
Shots on target: 4:1. Shots off target: 5:1. Corners: 5:4. Offsides: 4:1. Fouls: 7:10.
Referees: Tierney – Cann, McDonough
Attendance: 50956
Cards: 34. Romeu (SOT), 56. Lemina (SOT)
Penalty missed:
Ball possession: 61 % : 39 %.
Shots on target: 4:1. Shots off target: 5:1. Corners: 5:4. Offsides: 4:1. Fouls: 7:10.
Liverpool FC:
Alisson – Alexander-Arnold, Matip, V. van Dijk (55. Joe. Gomez), Robertson – Wijnaldum (70. Keïta), Хендерсон (C) – M. Salah, Shaqiri (46. Milner), Mané – Firmino.
Subs: Mignolet – Keïta, Fabinho, Milner, Sturridge, A. Moreno, Joe. Gomez.
Coach:
Southampton FC: A. McCarthy – Vestergaard, Hoedt, Bertrand (C) – Soares, P.-E. Höjbjerg, Romeu (55. Bednarek), Lemina, Targett (55. Armstrong) – Redmond – S. Long (79. Ch. Austin).
Subs: Gunn – Ward-Prowse, S. Davis, Jošida, Ch. Austin, Armstrong, Bednarek.
Coach:
Subs: Mignolet – Keïta, Fabinho, Milner, Sturridge, A. Moreno, Joe. Gomez.
Coach:
Southampton FC: A. McCarthy – Vestergaard, Hoedt, Bertrand (C) – Soares, P.-E. Höjbjerg, Romeu (55. Bednarek), Lemina, Targett (55. Armstrong) – Redmond – S. Long (79. Ch. Austin).
Subs: Gunn – Ward-Prowse, S. Davis, Jošida, Ch. Austin, Armstrong, Bednarek.
Coach:
Referees: Tierney – Cann, McDonough
Attendance: 50956
Southampton FC substitution: Oriol Romeu is replaced by Jan Bednarek.